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KMID : 0370019910050000027
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Chung-Ang Journal of Pharmacal Sciences
1991 Volume.5 No. 0 p.27 ~ p.38
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Studies on the Concurrent Administration of Medicines(Ⅷ)
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Abstract
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Gyegy-Tang has been known to be effective in the treatment of common cold, neuralgia, rheumatism, headache, and abdominal pain etc., in the chinese medicine.
This studies were undertaken to evaluate the anti-inflammatory, analgesic and antipyretic activities by concurrent administrations of Gyegy-Tang extract and acetaminophen.
The followings were obtained as results ;
1. On the paw edema induced by 1% carrageenin in rats, as a model symptom of acute inflammation, the combined oral administrations of Gyegy-Tang extract at a oral dose of 100㎎/㎏ was shown significant effectiveness in 4 hours respectively.
in case of chronic inflammation induced by Freund´s complete adjuvant, the combined administration of Gyegy-Tang extract at a oral dose of 200㎎/㎏ with acetaminophen at a oral dose of 200㎎/㎏ were remarkably exhibited anti-inflammatory activities in preventive and therapeutic effects.
2. Analgesic activities were examined on the writhing method in mice. The combined oral administration of Gyegy-Tang extract with acetaminophen by following doses ; 100㎎/㎏+200㎎/㎏, 200㎎/㎏+200㎎/㎏, the suppression rates were shown 92.67%, 93.72%, respectively.
3. The inhibitory activities of vascular permeability were studied on leakage of dye into ileum. The combined oral administration of Gyegy-Tang extact 100㎎/㎏ with acetaminophen 100㎎/㎏ was markedly suppressed leakage of dye as 47.89% which is nealy normal value.
4. Anti-pyretic activities were studied on the febrile rat induced by Typhoid vaccine. The combined oral administration of Gyegy-Tang extract 100㎎/㎏ with acetaminophen 200㎎/㎏ was suppressed 0.5℃ more than basal temperature.
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